Organic Acids
Medchemexpress LLC Substance P TFA (neurokinin P TFA) | 148470-19-3 | 99.3% | 1461.65 | 25 MG
Substance P TFA (neurokinin P TFA) is a CNS-penetrant neuropeptide that functions as a neurotransmitter and neuromodulator within the central nervous system. Its endogenous receptor is the neurokinin 1 receptor (NK1-receptor, NK1R), playing a crucial role in various biological activities.
- Acts as a CNS-penetrant neuropeptide
- Functions as a neurotransmitter and neuromodulator
- Endogenous receptor is neurokinin 1 receptor (NK1R)
- Appears as a white to off-white solid
- Soluble in H2O and PBS with ultrasonic assistance
- Involved in the internalization and recycling of the NK1R complex
- Related to peptides, hormones, and neuropeptides classifications
- Associated with research in cancer, neurological, and metabolic diseases
Medchemexpress LLC Aqp4 (201-220) Tfa | 99.9% | 2151.40 | 5 MG
Aqp4 (201-220) Tfa | 99.9% | 2151.40 | 5 MG
Medchemexpress LLC mP6 (TFA) | 2700321-79-3 | 990.15 | 1 MG
mP6 (Myr-FEEERA-OH) is a myristoylated peptide that functions as an Integrin β(3) Inhibitor. It inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function. Additionally, mP6 blocks the GTP usage of Rac1, Rap1, and Rab7, which effectively inhibits the infection of CHO-A24 cells.
- Myristoylated peptide
- Functions as an Integrin β(3) Inhibitor
- Inhibits the interaction of Gα13 with integrin β3
- Does not disrupt talin-dependent integrin function
- Blocks the GTP usage of Rac1, Rap1, and Rab7
- Effectively inhibits the infection of CHO-A24 cells
Medchemexpress LLC Astressin 2B TFA | 99.5% | 4041.69 (free base) | 5 MG
Astressin 2B TFA | 99.5% | 4041.69 (free base) | 5 MG
eMolecules 1188-02-9 | Ambeed | 2-Methylheptanoic acid | 5g | 632173640 | A861963 | MFCD00142944 | 144.214 | C8H16O2
Ambeed | N-(2-Methoxyethyl)but-3-en-1-amine | 250mg | 628567142 | A1483784 | 1251382-92-9 | MFCD16794419 | 129.203 | C7H15NO
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Apexbio Technology LLC Abietic acid 514-10-3 10mg
Abietic acid (CAS 514-10-3) is a small-molecule inhibitor targeting IKK and lipoxygenase It is designed to inhibit these enzymes thereby modulating NF- B signaling and inflammatory pathways Abietic acid exerts its biological activity primarily through inhibition of lipoxygenase activity and suppression of NF- B signaling pathways including the blockade of IKK In cell-based studies abietic acid demonstrates cytostatic activity with an IC50 of approximately 20 M in human lung cancer cell lines Based on these pharmacological properties abietic acid holds research potential in inflammation human cancer psoriasis sepsis-associated lung injury and non-small cell lung carcinoma
Apexbio Technology LLC Tiglic acid 80-59-1 200mg
Tiglic acid (CAS 80-59-1) is an unsaturated monocarboxylic acid found in natural sources such as Croton oil functioning as a plant-derived metabolite Studies have demonstrated that tiglic acid modulates specific signaling pathways and enzymatic activities within cells thereby influencing key biological processes Owing to its capacity to regulate cell signaling tiglic acid has been utilized in biomedical research related to cancer and inflammatory conditions serving as a valuable tool for investigating disease mechanisms and potential therapeutic strategies
Medchemexpress LLC JBJ-09-063 (TFA) | 99.6% | 670.67 | 25 MG
JBJ-09-063 TFA is a mutant-selective allosteric EGFR inhibitor that effectively reduces EGFR, Akt, and ERK1/2 phosphorylation. It is effective across EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models and can be used for researching EGFR-mutant lung cancer. This inhibitor is remarkably effective at inhibiting cell growth, leading to a significant increase in apoptosis, and exhibits favorable pharmacokinetics properties for good efficacy upon oral dosing.
- Mutant-selective allosteric EGFR inhibitor
- Reduces EGFR, Akt, and ERK1/2 phosphorylation
- Effective against EGFR TKI-sensitive and resistant models
- Suitable for EGFR-mutant lung cancer research
- Inhibits cell growth and increases apoptosis
- Favorable pharmacokinetics properties
- Stable for good efficacy upon oral dosing
Selleck Chemical LLC Citric acid
Citric acid is a weak organic acid that occurs naturally in citrus fruits It is an intermediate in the citric acid cycle
Medchemexpress LLC MC-VC-PAB-NH2 TFA | 1616727-21-9 | MFCD00935992 | 99.9% | 772.77 | C33H47F3N8O10 | 5 MG
MC-VC-PAB-NH2 TFA is a cleavable antibody-drug conjugate (ADC) linker used to attach cytotoxic payloads to antibodies and enable intracellular release through enzymatic cleavage. It contains a valine-citrulline dipeptide and a para-aminobenzyl self-immolative spacer and is supplied as the trifluoroacetate salt for stability in research applications.
- Cleavable valine-citrulline linker for cathepsin-mediated payload release.
- Para-aminobenzyl self-immolative spacer to facilitate efficient drug release.
- Supplied as a trifluoroacetate salt for improved stability and handling.
- High purity suitable for research use.
- Soluble in DMSO at high concentration; ultrasonic assistance may be required.
- Store sealed, away from moisture and light; follow recommended low-temperature storage for solutions.
Medchemexpress LLC TcY-NH2 TFA ((trans-cinnamoyl)-YPGKF-NH2 TFA) | 1262750-73-1 | 99.7% | 853.88 | 10 MG
tcY-NH2 TFA is a potent and selective PAR4 antagonist peptide. It is capable of inhibiting thrombin- and AY-NH2-induced platelet aggregation and endostatin release. This peptide is suitable for research applications in inflammation and immunology.
- Potent and selective PAR4 antagonist peptide.
- Inhibits thrombin- and AY-NH2-induced platelet aggregation.
- Prevents endostatin release.
- Suitable for inflammation and immunology research.
- Purity of 99.7%.
- Soluble in DMSO at 100 mg/mL.
- Demonstrated activity in various in vitro and in vivo models.
Medchemexpress LLC Huwentoxin IV | 526224-73-7 | >98% | 1 MG
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibiting neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4 with IC50s of 26, 150, 338, and 400 nM, respectively.
- Potent and selective sodium channel blocker
- Inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4
- IC50s of 26, 150, 338, and 400 nM, respectively